Journal: Frontiers in Immunology
Article Title: Fexuprazan safeguards the esophagus from hydrochloric acid-induced damage by suppressing NLRP1/Caspase-1/GSDMD pyroptotic pathway
doi: 10.3389/fimmu.2024.1410904
Figure Lengend Snippet: Differentially expressed genes (DEG) detected by RNA-seq. (A) Total RNA-sequencing on Het-1A cells pre-treated with 1% DMSO (control) or fexuprazan (test, FXZ, 30 µM) followed by HCl treatment. (B) Top ten functional categories of DEGs. (C) Volcano plot of cluster analysis for DEGs between immune response and inflammatory response of RNA-seq. (D) Heatmap of pyroptosis-related DEGs on Het-1A cells pre-treated with 1% DMSO (DMSO+HCl_1, DMSO+HCl_2) or fexuprazan (FXZ+HCl_1, FXZ +HCl_2).
Article Snippet: Total RNA sequencing procedures were performed by Ebiogen, Inc. (Seoul, Korea).
Techniques: RNA Sequencing, Control, Functional Assay